CHARMD

TOP

• Mutant: V715M
• Gene: UL54
• Virus: Human betaherpesvirus 5
• Strain:
• Reference: Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. (Mar 1996)


• Antiviral: Foscarnet
• EC50 ratio: 5.50
• Phenotype: High level resistance
• Passage: N/A
• Source: N/A
• Marker: Recombinant


• Details:
  • PRA, ELISA tests, flow cytometry and DNA-DNA hybridization assays, quantitative real-time PCR, reporter cell lines, polymerase biochemical assays, marker transfer


• Observations:
  • Autre publi ID : 24903568 12198609 23375740 23668613 26098499 9621055 12599051 Mutation fr?quemment retrouv?e chez les patients re?evant des CS h?matopo?etiques