CHARMD

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• Mutant: D588N
• Gene: UL54
• Virus: Human betaherpesvirus 5
• Strain:
• Reference: How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. (Jan 2005)


• Antiviral: Foscarnet
• EC50 ratio: 3.20-9.00
• Phenotype: Range of values between Intermediate level resistance and High level resistance
• Passage: N/A
• Source: N/A
• Marker: Recombinant


• Details:
  • PRA, ELISA tests, flow cytometry and DNA-DNA hybridization assays, quantitative real-time PCR, reporter cell lines, polymerase biochemical assays, marker transfer


• Observations:
  • Autre publi ID : 24903568 23985916 11595579 Mutation fr?quemment retrouv?e chez les patients re?evant des CS h?matopo?etiques