Recrutement


Postes à pourvoir

CDI / CDD

Aucune offre pour le moment.

Offre de thèse

Aucune offre pour le moment.

Offre de sujet de recherche

Offre de sujet de recherche Master 2 Bio-informatique

Location: University of Limoges, Limoges (France)
Research Unit: UMR 1092 RESINFIT – Antimicrobials: molecular supports of resistances and therapeutic innovations
Supervisor: Thibault Stalder and Marie-Cécile Ploy
When: Start January/February 2024
Contact information:

PROJECT BACKGROUND INFORMATION:

Antimicrobial resistance (AMR) in pathogens is a serious human health threat. The emergence of AMR is driven by the sharing of resistance genes between bacteria from animals, humans, and the environment. Therefore, to curtail the emergence and spread of AMR, research, surveillance, and intervention strategies must integrate One Health approaches. In this context, the UMR INSERM 1092 uses the One Heathframework to explore the eco-evolutionary trajectories of AMR spread and to enhance surveillance systems.

The acquisition of AMR by pathogens is mainly due to the sharing of AMR plasmids, mobile genetic elements that can confer resistance to various antibiotics. Evidence points out that those plasmids have and are crossing ecological boundaries between humans, animals, and the environment while rapidly spreading worldwide. However, we still poorly understand the trajectories leading these plasmids to hop between environmental, animal, or human ecosystems and end up in deadly human pathogens.

PROJECT DESCRIPTION:

This Master 2 project aims to contribute to identifying the key bacteria responsible for transferring AMR genes and plasmids across human, animal, and environmental habitats. Specifically, the student will contribute to adapting and validating a metagenomic approach to identify hosts of AMR genes and plasmids. This approach, called Hi-C+ combined chromosome conformation captures Hi-C with a target enrichment approach. In this project, the student will:

  • contribute to design baits for the target enrichment by mining AMR genes and plasmids databases, and,
  • develop a bioinformatic pipeline to determine the taxonomic affiliation of AMR genes and plasmids from Hi-C+ data.

Candidature spontanée

Selon les périodes, nous sommes en mesure d’accueillir des étudiants en stage de découverte ou de recherche. N’hésitez pas à nous soumettre votre demande le cas échéant. Si vous souhaitez nous faire part d’une candidature spontanée (poste en CDD, poste en CDI, poste relatif à un projet, etc.), prenez contact avec nous. Nous examinerons votre demande et vous répondrons dans les plus brefs délais.