Role: Associate professor

Theme: Microbiote and transplantation (project manager)

Location : CBRS 2nd floor university side – office 241

Phone number: 05 19 56 42 51

Email address: roland.lawson@unilim.fr

Keywords: Pharmacology, drug-induced iatrogenesis, gut microbiota, pharmacomicrobiomics, microbiota-derived metabolite signaling.

The unsatisfactory long-term survival rates of grafts and the issue of drug-induced iatrogenesis in organ transplantation necessitate the exploration of new avenues to improve patient care. In this context, one of the main challenges in transplant pharmacology is identifying new factors responsible for the variability in the response to immunosuppressants. Pharmacomicrobiomics, a new interdisciplinary field born at the intersection of pharmacology, genomics, and microbiology, analyzes the impact of microbiota variations on the efficacy and toxicity of medications. Applying pharmacomicrobiomics to the field of organ transplantation helps to better understand the dynamic changes in the gut microbiota post-transplantation and provides new insights to optimize the pharmacological profile and tolerance of immunosuppressants.

• Pharmacodynamics and Molecular Pharmacology (LAS, DFGSP2, DFGSP3, Faculty of Pharmacy)
• Cardiovascular Pharmacology (DFASP1, Faculty of Pharmacy)
• Toxicomicrobiomics (DFASP1, Faculty of Pharmacy)
• Basics of Pharmacometrics and Experimental Pharmacology (DFASP1, DFASP2, M2 Health Product Development, Faculty of Pharmacy)
• Pharmacology of Immunosuppressants (DFASP1, Faculty of Pharmacy)
• Scientific English (M2 Genomics and Biotechnology, Faculty of Science and Technology) 

Since 09/2020: Associate Professor of Pharmacology (Faculty of Pharmacy, Limoges) and Head of the “Microbiota and Transplantation” research axis at UMR 1248.

2018-2023: Faculty of Pharmacy, University of Limoges, Continuing Education Intern, Doctoral Thesis in Pharmacy (Therapeutic Potential of Bacterial Beta-Glucuronidase Inhibitors in Mycophenolate-Induced Enteropathy).

2016-2020: Postdoctoral Researcher, Centre for Biology and Health Research (CBRS), Inserm U1248; Teaching Assistant, Departments of Pharmacology and Toxicology, Faculty of Pharmacy, University of Limoges.

2015-2016: Temporary Teaching and Research Assistant in Pharmacology (CNU 86), EA 4475, Laboratory of Cerebral Circulation Pharmacology, Faculty of Pharmacy, University Paris Descartes.

2014-2015: Temporary Teaching and Research Assistant in Physiology (CNU 66), EA 3922, Laboratory of Biochemistry and Cell Biology, UFR-Sciences and Techniques, University of Franche-Comté.

2010-2014: Contractual Doctoral Student in Pharmacology with Teaching Mission, EA 7296, Laboratory of Neurobiology and Cardiovascular Pharmacology, Faculty of Medicine, University of Strasbourg.

2004-2010: Faculty of Health Sciences, University of Abomey-Calavi (Benin), Doctoral Thesis in Pharmacy (Effect of Gmelina arborea, Roxb (Verbenaceae) on Hypertension Induced in Wistar Rats).

2009-2010: Faculty of Pharmacy, University of Strasbourg, Master’s in Pharmacology (Involvement of Serotonin and 5-HT2 Receptors in Carcinoid Heart Disease).

Membership in Scientific Societies

• French Society of Pharmacology and Therapeutics (SFPT, since 2010)
• European Association of Clinical Pharmacology and Therapeutics (EACPT, since 2020)
• International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT), Member of the Expert Committee on Immunosuppressors (since 2021)

Missions

• Head of Pedagogical Affairs (since September 2021) within the Board of the Association of Pharmacology Teachers in Pharmacy Faculties (AEPFP)
• Representative Member of UMR1248 (Pharmacology and Transplantation) within the Board of the Doctoral School of Biology, Chemistry, and Health (BCS) at the University of Limoges
• Delegate for International Cooperation, Faculty of Pharmacy, University of Limoges