CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    C325Y

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Letermovir 8796.00 High level resistance Laboratory strain, Clinical Isolate Recombinant Details Geno- and phenotypic characterization of human cytomegalovirus mutants selected in vitro after letermovir (AIC246) exposure. ( 2014)

    Mutations at the same locus:

    Mutant Resistances
    C325F Letermovir: High level resistance
    C325R Letermovir: High level resistance
    C325W Letermovir: High level resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230