CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    V236M

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Letermovir 45.00 High level resistance Laboratory strain, Clinical Isolate Recombinant Details Geno- and phenotypic characterization of human cytomegalovirus mutants selected in vitro after letermovir (AIC246) exposure. ( 2014)
    Maribavir 0.12 Possible hypersensitivity, no resistance Laboratory strain Recombinant Details Antiviral activity of maribavir in combination with other drugs active against human cytomegalovirus. (Sep 2018)

    Mutations at the same locus:

    Mutant Resistances
    V236A Letermovir: Low level resistance
    V236L Letermovir: High level resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230