CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database

V236L

Virus: Human betaherpesvirus 5
Gene: UL56
Resistance summary:*
- Letermovir: High level resistance

*If there is more than one line per antiviral, please refer to the table below

Antiviral assays:

Antiviral	EC50 ratio	Phenotype	Strain	Source	Marker	Assay	Reference
Letermovir	14.00	High level resistance	N/A	Laboratory strain	Recombinant	Details	Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance. (Oct 2015)

Mutations at the same locus:

Mutant	Resistances
V236A	Letermovir: Low level resistance
V236M	Letermovir: High level resistance

Tilloy et al., 2024

Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230