CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    Y617del

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Maribavir 372.00 High level resistance Laboratory strain, Clinical Isolate Details Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions. ( 2014)
    Ganciclovir 10.00 High level resistance Laboratory strain, Clinical Isolate Recombinant Details Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions. ( 2014)

    Mutations at the same locus:

    Mutant Resistances
    Y617H Ganciclovir: No resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230