CHARMD
Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database
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Last update : Mon 20 Apr 2026
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Measure details
Mutant:
Y617del
Gene:
UL97
Virus:
Human betaherpesvirus 5
Strain:
Reference:
Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions. ( 2014)
Antiviral:
Ganciclovir
EC50 ratio: 10.00
Phenotype: High level resistance
Passage: N/A
Source: Laboratory strain, Clinical Isolate
Marker: Recombinant
Details:
PRA, ELISA tests, flow cytometry and DNA-DNA hybridization assays, quantitative real-time PCR, reporter cell lines, polymerase biochemical assays, marker transfer, SEAP
Observations:
No observations associated
Tilloy
et al.
, 2024
Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230