CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


  • TOP

    C480R

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Maribavir 243.00 High level resistance Laboratory strain, Clinical Isolate Recombinant Details Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions. ( 2014)
    Ganciclovir 9.00 High level resistance Laboratory strain, Clinical Isolate Recombinant Details Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions. ( 2014)

    Mutations at the same locus:

    Mutant Resistances
    C480F Maribavir: High level resistance
    C480F Ganciclovir: Low level resistance
    C480F Ganciclovir: Low level resistance
    C480F Maribavir: High level resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230