Inhibition parameters for the A and B isozymes of arylesterase. Results are expressed as pC50 = - log C50, where C50 denotes the inhibitor concentration (in mol/L) giving 50% inhibition.
Solvent | pC50 (A) | pC50 (B) |
---|---|---|
Acetone | 1.19 | 1.09 |
Acetonitrile | 0.46 | 0.40 |
Dimethylacetamide | 1.61 | 1.61 |
Dimethylformamide | 1.44 | 1.53 |
Dimethylsulfoxide | 0.83 | 0.75 |
Dioxan | 1.16 | 1.09 |
Ethyl acetate | 1.02 | 0.95 |
Hexamethylphosphoramide | 2.38 | 2.34 |
Nitromethane | 1.26 | 1.27 |
Propylene carbonate | 1.87 | 2.07 |
Tetrahydrofuran | 1.94 | 1.93 |
Triethylphosphate | 2.04 | 2.06 |