Table 4. Inhibition parameters.


Inhibition parameters for the A and B isozymes of arylesterase. Results are expressed as pC50 = - log C50, where C50 denotes the inhibitor concentration (in mol/L) giving 50% inhibition.



Solvent pC50 (A) pC50 (B)
Acetone 1.19 1.09
Acetonitrile 0.46 0.40
Dimethylacetamide 1.61 1.61
Dimethylformamide 1.44 1.53
Dimethylsulfoxide 0.83 0.75
Dioxan 1.16 1.09
Ethyl acetate 1.02 0.95
Hexamethylphosphoramide 2.38 2.34
Nitromethane 1.26 1.27
Propylene carbonate 1.87 2.07
Tetrahydrofuran 1.94 1.93
Triethylphosphate 2.04 2.06