{"id":617,"date":"2018-05-15T17:05:18","date_gmt":"2018-05-15T15:05:18","guid":{"rendered":"http:\/\/www.unilim.fr\/ippritt-dev\/?p=617"},"modified":"2023-03-08T12:02:21","modified_gmt":"2023-03-08T11:02:21","slug":"review-pharmacokinetic-models-to-assist-the-prescriber-in-choosing-the-best-tacrolimus-dose","status":"publish","type":"post","link":"https:\/\/www.unilim.fr\/p-and-t\/en\/2018\/05\/15\/review-pharmacokinetic-models-to-assist-the-prescriber-in-choosing-the-best-tacrolimus-dose\/","title":{"rendered":"Review: Pharmacokinetic models to assist the prescriber in choosing the best tacrolimus dose"},"content":{"rendered":"<p>Due to a high inter-individual variability in its <a title=\"Learn more about Pharmacokinetics\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pharmacokinetics\">pharmacokinetics<\/a>, tacrolimus dose individualization is mandatory. Even though the expert opinion has defined the area under the curve (AUC) as the best marker to use when performing dose adjustment of tacrolimus, most centres only use <a title=\"Learn more about Trough level\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/trough-level\">trough levels<\/a>. Multiple targets have been proposed for this parameter and physicians rely largely on their personal experience when making a decision about dose adjustment. Several population pharmacokinetics models (POPPK) allowing AUC determination have been developed, but only a few are actually used in routine practice for dose individualization. These POPPK models can also be used to perform Monte Carlo simulations that help to establish different dosing rules or to anticipate the pharmacokinetics of tacrolimus in particular populations, without conducting clinical trials. Various available applications of POPPK models to assist the prescriber in choosing the best tacrolimus dose are discussed in this paper as well as the difficulties in introducing them into routine <a title=\"Learn more about Therapeutic drug monitoring\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/therapeutic-drug-monitoring\">therapeutic drug monitoring<\/a>.<\/p>\n<p><strong>Authors<\/strong><\/p>\n<p><span class=\"content\"><span class=\"text given-name\">J.B.\u00a0<\/span><span class=\"text surname\">Woillard<span style=\"font-size: 13.3333px\">,\u00a0<\/span><\/span><\/span><span class=\"content\"><span class=\"text given-name\">F.\u00a0<\/span><span class=\"text surname\">Saint-Marcoux<span style=\"font-size: 13.3333px\">,\u00a0<\/span><\/span><\/span><span class=\"content\"><span class=\"text given-name\">J.\u00a0<\/span><span class=\"text surname\">Debord<span style=\"font-size: 13.3333px\">,\u00a0<\/span><\/span><\/span><span class=\"content\"><span class=\"text given-name\">A.\u00a0<\/span><span class=\"text surname\">\u00c5sberg<\/span><\/span><\/p>\n<p><strong>For more details<\/strong><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.phrs.2018.02.016\">10.1016\/j.phrs.2018.02.016\u00a0<\/a>and\u00a0<a href=\"mailto:jean-baptiste.woillard@unilim.fr\" target=\"_self\">jean-baptiste.woillard@unilim.fr<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-618\" src=\"http:\/\/www.unilim.fr\/ippritt\/wp-content\/uploads\/sites\/56\/2018\/05\/TOC_JB_PharmacolRes-1024x769.jpg\" alt=\"\" width=\"1024\" height=\"769\" srcset=\"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2018\/05\/TOC_JB_PharmacolRes-1024x769.jpg 1024w, https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2018\/05\/TOC_JB_PharmacolRes-300x225.jpg 300w, https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2018\/05\/TOC_JB_PharmacolRes-768x577.jpg 768w, https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2018\/05\/TOC_JB_PharmacolRes-640x480.jpg 640w, https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2018\/05\/TOC_JB_PharmacolRes.jpg 1180w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Due to a high inter-individual variability in its pharmacokinetics, tacrolimus dose individualization is mandatory. Even though the expert opinion has defined the area under the curve (AUC) as the best marker to use when performing dose adjustment of tacrolimus, most centres only use trough levels. Multiple targets have been proposed for this parameter and physicians [&hellip;]<\/p>\n","protected":false},"author":120,"featured_media":618,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"footnotes":""},"categories":[33],"tags":[],"class_list":["post-617","post","type-post","status-publish","format-gallery","has-post-thumbnail","hentry","category-articles","post_format-post-format-gallery"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Review: Pharmacokinetic models to assist the prescriber in choosing the best tacrolimus dose - Pharmacologie &amp; Transplantation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unilim.fr\/p-and-t\/en\/2018\/05\/15\/review-pharmacokinetic-models-to-assist-the-prescriber-in-choosing-the-best-tacrolimus-dose\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Review: Pharmacokinetic models to assist the prescriber in choosing the best tacrolimus dose - Pharmacologie &amp; Transplantation\" \/>\n<meta property=\"og:description\" content=\"Due to a high inter-individual variability in its pharmacokinetics, tacrolimus dose individualization is mandatory. Even though the expert opinion has defined the area under the curve (AUC) as the best marker to use when performing dose adjustment of tacrolimus, most centres only use trough levels. Multiple targets have been proposed for this parameter and physicians [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unilim.fr\/p-and-t\/en\/2018\/05\/15\/review-pharmacokinetic-models-to-assist-the-prescriber-in-choosing-the-best-tacrolimus-dose\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacologie &amp; Transplantation\" \/>\n<meta property=\"article:published_time\" content=\"2018-05-15T15:05:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-08T11:02:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2018\/05\/TOC_JB_PharmacolRes.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1180\" \/>\n\t<meta property=\"og:image:height\" content=\"886\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"dimep01\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"dimep01\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/2018\/05\/15\/review-pharmacokinetic-models-to-assist-the-prescriber-in-choosing-the-best-tacrolimus-dose\/\",\"url\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/2018\/05\/15\/review-pharmacokinetic-models-to-assist-the-prescriber-in-choosing-the-best-tacrolimus-dose\/\",\"name\":\"Review: Pharmacokinetic models to assist the prescriber in choosing the best tacrolimus dose - Pharmacologie &amp; 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