{"id":2926,"date":"2025-03-05T23:00:00","date_gmt":"2025-03-06T11:18:37","guid":{"rendered":"https:\/\/www.unilim.fr\/p-and-t\/?page_id=2926"},"modified":"2025-03-10T09:42:07","modified_gmt":"2025-03-10T08:42:07","slug":"florent-di-meo","status":"publish","type":"page","link":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/","title":{"rendered":"Florent Di Meo"},"content":{"rendered":"
\n
\n
\n
\n \n \n <\/a>\n <\/div>\n <\/div>\n
\n
\n \n

Role: <\/strong>PharmD, PhD, Inserm Researcher (CRCN) <\/p>\n

Theme: <\/strong>Pharmacology of immunosuppressive drugs in transplantation <\/p>\n

Location :<\/strong> CBRS 2nd floor university side – office 234 <\/p>\n

Phone number: <\/strong>05 19 56 42 76 <\/p>\n

Email address:<\/strong> florent.di-meo@inserm.fr<\/p>\n\n\n\n
\"\"<\/a><\/td>\n<\/td>\n\"\"<\/a><\/td>\n<\/td>\n\"\"<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n
\n \n \n
\n\n

\n <\/i>\n Research <\/h3>\n <\/div>\n
\n \n

Keywords: Structural and Computational Pharmacology, Molecular Modeling, Membrane Transporters, Local Pharmacokinetics<\/em><\/p>\n

Understanding the involvement of membrane transporters in the variability of treatment responses at the local pharmacokinetic scale using multi-scale methods:<\/p>\n

    \n
  1. Understanding the dynamics of ABC and MFS membrane transporters of pharmacological interest and their interactions with the environment (e.g., doi: 10.1111\/bcpt.13871; 10.1016\/j.biopha.2023.114342; 10.1038\/s42003-023-04537-3; 10.1038\/s41598-022-10755-2)<\/li>\n
  2. Study of non-covalent interactions governing ligand-protein binding modes (e.g., doi: 10.1038\/s41598-024-51412-0; 10.1016\/j.lfs.2024.122792; 10.1016\/j.phrs.2024.107438)<\/li>\n
  3. Study of the structural impact on ABC transporters caused by mutations or genetic polymorphisms \u2013 ANR PRCE 2021 RAPRACLID (Partner)<\/li>\n
  4. Development of organ-on-chip models to understand the impact of inter-organ communication mediated by membrane transporters according to the “Remote Sensing Signalling Theory”<\/li>\n<\/ol>\n

    <\/p>\n

    \"\"<\/a><\/p>\n

    \"\"<\/a><\/p>\n

    Coordinator of an ANR JCJC (IMOTEP \u2013 2019-2023) & Partner in an ANR PRCE (RAPRACLID \u2013 2021-2025). <\/p>\n

    Recipient of the 2014 Gaston Berthier Prize from the Francophone Network of Theoretical Chemistry (Now GDR Th\u00e9MoSia). <\/p>\n

    Member of the consortium awarded the Dalton Horizon Prize by the “Royal Society of Chemistry” (RSC).<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

    \n
    \n
    \n \n \n
    \n\n

    \n <\/i>\n Teaching <\/h3>\n <\/div>\n
    \n \n

    Lecturer in the Master’s program in Biology Health \u2013 Genomics & Biotechnology track: Introduction to Structural Biology (M1 & M2).<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

    \n
    \n
    \n \n \n
    \n\n

    \n <\/i>\n Career path <\/h3>\n <\/div>\n
    \n \n

    Degrees:<\/strong><\/span><\/p>\n

    2009: Doctorate in Pharmacy (PharmD), Faculty of Medicine & Pharmacy \u2013 University of Limoges, France<\/p>\n

    2012: PhD in Science \u2013 Physical and Theoretical Chemistry, University of Limoges, France<\/p>\n

    2019: Habilitation to Supervise Research, University of Limoges, France.<\/p>\n

    Professional Experience:<\/strong><\/span><\/p>\n

    2009-2012: PhD student, “Molecular and Supramolecular Highlights on Reactivity and Optoelectronics of Natural Polyphenols” – LCSN EA1069, University of Limoges, France<\/p>\n

    2012-2013: Postdoctoral researcher, “Structural properties, optoelectronics, and oxidative reactivity of biologically active compounds”, Department of Biophysics, University of Limoges, France<\/p>\n

    2013-2015: Postdoctoral researcher, “Chiral optoelectronics of biological macromolecules and nanomaterials”, Theoretical Chemistry group, Department of Physics, Chemistry & Biology (IFM), Link\u00f6ping University, Sweden<\/p>\n

    2016-2018: Postdoctoral researcher, “Modeling membrane crossing of drugs by means of molecular dynamics”, Inserm U1248 Pharmacology & Transplantation, University of Limoges, France<\/p>\n

    Since 2018: Inserm Researcher (CRCN), Inserm U1248 Pharmacology & Transplantation, University of Limoges, France<\/p>\n

    Since 2024: Deputy Director US Inserm 42\/UAR CNRS 2015 BISCEm, University of Limoges, France<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

    \n
    \n
    \n \n \n
    \n\n

    \n <\/i>\n Other information <\/h3>\n <\/div>\n
    \n \n

    More than 50 articles in journals indexed in Clarivate \u2013 Web of Science H-index = 21 (Web of Science, October 2024)\ufeff\u200b<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n \n","protected":false},"excerpt":{"rendered":"","protected":false},"author":239,"featured_media":0,"parent":2881,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-le.php","meta":{"footnotes":""},"class_list":["post-2926","page","type-page","status-publish","hentry"],"yoast_head":"\nFlorent Di Meo - Pharmacologie & Transplantation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Florent Di Meo - Pharmacologie & Transplantation\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacologie & Transplantation\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-10T08:42:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2024\/07\/orcid-300x102.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/\",\"url\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/\",\"name\":\"Florent Di Meo - Pharmacologie & Transplantation\",\"isPartOf\":{\"@id\":\"https:\/\/www.unilim.fr\/p-and-t\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2024\/07\/orcid-300x102.png\",\"datePublished\":\"2025-03-06T11:18:37+00:00\",\"dateModified\":\"2025-03-10T08:42:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#primaryimage\",\"url\":\"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2024\/07\/orcid-300x102.png\",\"contentUrl\":\"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2024\/07\/orcid-300x102.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Members\",\"item\":\"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Florent Di Meo\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.unilim.fr\/p-and-t\/#website\",\"url\":\"https:\/\/www.unilim.fr\/p-and-t\/\",\"name\":\"Pharmacologie & Transplantation\",\"description\":\"From computer and bench to bedside\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.unilim.fr\/p-and-t\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Florent Di Meo - Pharmacologie & Transplantation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/","og_locale":"en_US","og_type":"article","og_title":"Florent Di Meo - Pharmacologie & Transplantation","og_url":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/","og_site_name":"Pharmacologie & Transplantation","article_modified_time":"2025-03-10T08:42:07+00:00","og_image":[{"url":"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2024\/07\/orcid-300x102.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/","url":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/","name":"Florent Di Meo - Pharmacologie & Transplantation","isPartOf":{"@id":"https:\/\/www.unilim.fr\/p-and-t\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#primaryimage"},"image":{"@id":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#primaryimage"},"thumbnailUrl":"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2024\/07\/orcid-300x102.png","datePublished":"2025-03-06T11:18:37+00:00","dateModified":"2025-03-10T08:42:07+00:00","breadcrumb":{"@id":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#primaryimage","url":"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2024\/07\/orcid-300x102.png","contentUrl":"https:\/\/www.unilim.fr\/p-and-t\/wp-content\/uploads\/sites\/80\/2024\/07\/orcid-300x102.png"},{"@type":"BreadcrumbList","@id":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/florent-di-meo\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.unilim.fr\/p-and-t\/en\/"},{"@type":"ListItem","position":2,"name":"Members","item":"https:\/\/www.unilim.fr\/p-and-t\/en\/members\/"},{"@type":"ListItem","position":3,"name":"Florent Di Meo"}]},{"@type":"WebSite","@id":"https:\/\/www.unilim.fr\/p-and-t\/#website","url":"https:\/\/www.unilim.fr\/p-and-t\/","name":"Pharmacologie & Transplantation","description":"From computer and bench to bedside","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.unilim.fr\/p-and-t\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.unilim.fr\/p-and-t\/en\/wp-json\/wp\/v2\/pages\/2926","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unilim.fr\/p-and-t\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.unilim.fr\/p-and-t\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.unilim.fr\/p-and-t\/en\/wp-json\/wp\/v2\/users\/239"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unilim.fr\/p-and-t\/en\/wp-json\/wp\/v2\/comments?post=2926"}],"version-history":[{"count":2,"href":"https:\/\/www.unilim.fr\/p-and-t\/en\/wp-json\/wp\/v2\/pages\/2926\/revisions"}],"predecessor-version":[{"id":3043,"href":"https:\/\/www.unilim.fr\/p-and-t\/en\/wp-json\/wp\/v2\/pages\/2926\/revisions\/3043"}],"up":[{"embeddable":true,"href":"https:\/\/www.unilim.fr\/p-and-t\/en\/wp-json\/wp\/v2\/pages\/2881"}],"wp:attachment":[{"href":"https:\/\/www.unilim.fr\/p-and-t\/en\/wp-json\/wp\/v2\/media?parent=2926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}