Role: MD, PhD, Professor of Medical Pharmacology, Director of U1248 Inserm/University of Limoges

Theme: Pharmacology of immunosuppressive drugs in transplantation

Location : CBRS 2nd floor – hospital side

Phone number: +33 (0)5 55 05 64 18

Email address: pierre.marquet@unilim.fr

More than 350 articles in journals indexed in the Science Citation Index H-index = 54 (Web of Science)

Research

Keywords: Immunosuppressant pharmacology, pharmacometrics, pharmacoepidemiology. Development and evaluation of precision medicine tools in organ transplantation:

  1. Development and international deployment of the Immunosuppressants Bayesian Adaptation Expert System for (IBSA) (https://abis.chu-limoges.fr/login)

  2. Clinical validation (doi/10.1111/j.1600-6143.2007.01983.x) and epidemiological validation (doi: 10.1002/cpt.3206) of mycophenolate mofetil dose adaptation, resulting in a 60% decrease in episodes of acute kidney graft rejection.

  3. Coordination of the European research program Biomarkers of Kidney Graft Injuries (BIOMARGIN), FP7 HEALTH.2012.1.4-1 (https://www.biomargin.eu)

  4. Coordination of the research program Relationships Between Exposure and Effects of Immunosuppressants in Kidney Transplantation (REXETRIS), winner of the first project call from the Health Data Hub (https://www.health-data-hub.fr/partenariats/rexetris)

  5. Principal investigator for 16 clinical or pharmacoepidemiological studies since 1997 (including two as part of BIOMARGIN, 1 national PHRC, 2 inter-regional PHRCs, and 2 regional PHRCs).

Teaching

  • Pharmacology in the Specific Health Access Pathway (PASS)
  • Pharmacology in the 2nd, 3rd, and 4th years of Medicine
  • Pharmacology of immunomodulatory drugs in the 2nd year Master’s program in Immune Interactions and Cellular Engineering (I3C – Universities of Franche-Comté, Paris-Saclay, Tours, Poitiers, and Limoges)

Career Path

1986: Doctorate in Medicine, University of Limoges.

1992: PhD in Life and Health Sciences (option: Physiology), University Paris V, Cochin Port-Royal Medical Faculty.

1998: Habilitation to Supervise Research (HDR), University of Limoges.

1998-2001: Associate Professor – Hospital Practitioner in Pharmacology, Faculty of Medicine, Limoges.

Since 2001: Full Professor of Universities – Hospital Practitioner in Pharmacology, Faculty of Medicine, Limoges.

2000-2007: Director of EA 1313 “Development and Effects of Drugs in the Body” (DEXO)

Since 2007: Director of UMR850 then U1248 “Pharmacology & Transplantation”, Inserm / University of Limoges / CHU Limoges

Since 2011: Head of the Department of Pharmacology, Toxicology, and Pharmacovigilance, CHU Limoges

Secretary (2007-2009), President-Elect (2009-2011), President (2011-2013), and Past-President (2013-2015) of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT)

Board Member (2008-2015) and Founding President of the Scientific Council of the French Society of Pharmacology and Therapeutics

Member of the CSS8 “Health Technologies” Committee of INSERM (2012-2016)

President of the Biomedical and Public Health Research Committee (CRBSP) of Limoges (2007-2012) and Vice-President for Research on the Board of Directors of CHU Limoges (2012-2016)

President-Elect (2019-2021), President (2021-2023), and Past-President (2023-2025) of the European Association of Clinical Pharmacology and Therapeutics (EACPT)

Since 2022: Treasurer of the International Union of Basic and Clinical Pharmacology (IUPHAR)

Since 2024: Scientific Site Coordinator for INSERM