Role: PharmD, PhD, Inserm Researcher (CRCN)

Theme: Pharmacology of immunosuppressive drugs in transplantation

Location : CBRS 2nd floor university side – office 234

Phone number: 05 19 56 42 76

Email address: florent.di-meo@inserm.fr

Keywords: Structural and Computational Pharmacology, Molecular Modeling, Membrane Transporters, Local Pharmacokinetics

Understanding the involvement of membrane transporters in the variability of treatment responses at the local pharmacokinetic scale using multi-scale methods:

1. Understanding the dynamics of ABC and MFS membrane transporters of pharmacological interest and their interactions with the environment (e.g., doi: 10.1111/bcpt.13871; 10.1016/j.biopha.2023.114342; 10.1038/s42003-023-04537-3; 10.1038/s41598-022-10755-2)
2. Study of non-covalent interactions governing ligand-protein binding modes (e.g., doi: 10.1038/s41598-024-51412-0; 10.1016/j.lfs.2024.122792; 10.1016/j.phrs.2024.107438)
3. Study of the structural impact on ABC transporters caused by mutations or genetic polymorphisms – ANR PRCE 2021 RAPRACLID (Partner)
4. Development of organ-on-chip models to understand the impact of inter-organ communication mediated by membrane transporters according to the “Remote Sensing Signalling Theory”

Coordinator of an ANR JCJC (IMOTEP – 2019-2023) & Partner in an ANR PRCE (RAPRACLID – 2021-2025).

Recipient of the 2014 Gaston Berthier Prize from the Francophone Network of Theoretical Chemistry (Now GDR ThéMoSia).

Member of the consortium awarded the Dalton Horizon Prize by the “Royal Society of Chemistry” (RSC).

Lecturer in the Master’s program in Biology Health – Genomics & Biotechnology track: Introduction to Structural Biology (M1 & M2).

Degrees:

2009: Doctorate in Pharmacy (PharmD), Faculty of Medicine & Pharmacy – University of Limoges, France

2012: PhD in Science – Physical and Theoretical Chemistry, University of Limoges, France

2019: Habilitation to Supervise Research, University of Limoges, France.

Professional Experience:

2009-2012: PhD student, “Molecular and Supramolecular Highlights on Reactivity and Optoelectronics of Natural Polyphenols” – LCSN EA1069, University of Limoges, France

2012-2013: Postdoctoral researcher, “Structural properties, optoelectronics, and oxidative reactivity of biologically active compounds”, Department of Biophysics, University of Limoges, France

2013-2015: Postdoctoral researcher, “Chiral optoelectronics of biological macromolecules and nanomaterials”, Theoretical Chemistry group, Department of Physics, Chemistry & Biology (IFM), Linköping University, Sweden

2016-2018: Postdoctoral researcher, “Modeling membrane crossing of drugs by means of molecular dynamics”, Inserm U1248 Pharmacology & Transplantation, University of Limoges, France

Since 2018: Inserm Researcher (CRCN), Inserm U1248 Pharmacology & Transplantation, University of Limoges, France

Since 2024: Deputy Director US Inserm 42/UAR CNRS 2015 BISCEm, University of Limoges, France

More than 50 articles in journals indexed in Clarivate – Web of Science H-index = 21 (Web of Science, October 2024)​