Role: Researcher

Theme: Pharmacomicrobiomics

Location : CBRS (university building) 2nd floor – office 237

Email address: anne.druilhe@inserm.fr

Within the Pharmacomicrobiomics group, we aim to study the impact of the digestive microbial flora, known as the microbiota, on orally administered immunosuppressants, and conversely, to understand the effect of medications on the digestive microbiota and their consequences in transplant patients. My projects focus on understanding the mechanisms of the adverse digestive effects of immunosuppressive drugs, particularly on the role of immunoglobulin A, using experimental approaches including the analysis of human samples and, when there is no other alternative, the use of rodent models. Immunoglobulin A is an essential molecule of the immune system that is a major regulator of the digestive microbiota. In addition to my research activities, I help research staff at the local, regional, and national levels in the ethical and responsible use of animals in science, ensuring compliance with current regulations. I contribute to the ethical evaluation of research projects involving animals, as part of a dedicated ethics committee in Nouvelle-Aquitaine area, I am deeply involved in the training of animal users and the education of various audiences on this activity. I also lead the Inserm AnimalPharm project, which aims to provide recommendations on the administration of substances to animals used in science.

Use of Animals in Science:

• Coordinator for regulatory training programs at the University of Limoges,• Teacher in regulatory training programs at the University of Limoges, the University of Poitiers, and the ONIRIS National Veterinary School (Nantes),
• Teacher in continuing education programs for maintenance of skills in the fields of ethics and regulation, and in the EDA (Experimental Design Assistant) program proposed by Inserm in collaboration with the UK-based NC3R center,
• Teacher in an initial training module at the Faculty of Pharmacy of the University of Limoges and in a medical ethics diploma at the Faculty of Medicine of the University of Limoges.

Target audience for these training programs: Master students at the Faculty of Fundamental and Applied Sciences of Poitiers and at the Faculty of Technical Sciences of Limoges, students from the Faculty of Pharmacy of Limoges and Poitiers, technical staff, phD students, and researchers from Inserm, CNRS, INRAE laboratories, and universities of Limoges, Poitiers, Bordeaux, Tours, and the CHU of Limoges.

Since 2022          P&T Laboratory, Inserm U1248, University of Limoges, CHU of Limoges (researcher)

2017-2021           Research Animal Facility and BISCEm Technology Platform, Inserm US 042, CNRS UAR 2015, University of Limoges and CHU of Limoges (director)

2013-2016           CRIBL Laboratory, CNRS U7276, Inserm U1262, University of Limoges (researcher)

2007-2012           Growth & Signaling Research Center, Inserm U845, University Paris 5 (researcher)

2001-2006           Inserm U700 Laboratory, University Paris 7 (researcher)

1999-2000           Center for Apoptosis Research, Thomas Jefferson University, Philadelphia, USA (postdoctoral researcher)

1994-1998           Inserm U485 Laboratory, Institut Pasteur, Paris (DEA intern and then PhD student)

Dissemination of scientific culture:

• Coordinator of the workshop LuSci (primary school and 6th grade students, 2013-2018), the project “Sciences and Society of the Future” (all levels, Isle Middle School, since 2017, in collaboration with the Space for Ethical Reflection ERENA), the Biology Day (secondary school teachers, since 2022), and the e.LAB project (virtual support for high school students, since 2024).
• Contribution in various events (Science Festival, European Researchers’ Night, ‘Scientibus’ of the University of Limoges, project ‘Science with and for Society – SAPS’ of the University of Limoges, and the National Biology Olympiads), conferences on research careers, and tutor of middle and high school students, since 2013.
• • Member of the board of the Scientific, Technical, and Industrial Culture Center Récréasciences, Limoges, since 2019.

Expert for the Ministry of Higher Education and Research for the recruitment and the promotion of university technical staff, since 2016.
Employee representative for Inserm, since 2019, involved in commission on health, safety and working conditions.