{"id":1959,"date":"2025-01-13T15:15:21","date_gmt":"2025-01-13T15:15:21","guid":{"rendered":"http:\/\/www.unilim.fr\/labex_sigmalim\/?p=1959"},"modified":"2025-02-05T11:44:37","modified_gmt":"2025-02-05T11:44:37","slug":"label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials","status":"publish","type":"post","link":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en","title":{"rendered":"Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials"},"content":{"rendered":"<p>Rapid plasmonic biosensing offers great potential in the fields of early disease diagnosis and molecular biology research. However, it was still difficult for conventional plasmonic sensors to achieve higher sensitivity without secondary amplification such as plasmonic nanoparticles. To solve this problem, a team of researchers from L2n (CNRS- University of Troyes), the Biomedical Engineering Department of the Chinese University of Hong Kong and the XLIM Research Institute (University of Limoges &#8211; CNRS), have developed a plasmonic biosensor based on phase singularity-enhanced lateral position shifting. This work builds on research supported by LABEX \u2211-LIM. This singularity appears as an abrupt phase delay at the dark point of reflection from the resonant plasmonic substrate, leading to a giant position shift on the reflected beam. This new configuration achieved a record largest position shift of 439.3 \u03bcm measured in calibration experiments with an ultra-high sensitivity of 1,72 x 10 <sup>8<\/sup> nm \u00b7 RIU-<sup>1<\/sup> (refractive index unit).<\/p>\n<p>In targeted biosensing experiments, the optimized sensor succeeded in detecting small cytokine biomarkers (TNF- and IL-6) with the lowest concentration of 1 x 10 <sup>x 16<\/sup> M. These two molecules are key pro-inflammatory cancer markers in clinical diagnosis, which cannot be directly monitored by current clinical techniques.<\/p>\n<p>&nbsp;<\/p>\n<p><em>Figure: Principle and optical setup of singular phase enhanced plasmonic sensor.<\/em><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong><u>About the publication <\/u><\/strong><\/p>\n<p><strong>Journal : Nature &#8211; <\/strong><a href=\"https:\/\/www.nature.com\/lsa\"><strong>Light: Science &amp; Applications<\/strong><\/a><strong> volume\u00a013, Article\u00a0number:\u00a02 (2024)<\/strong><\/p>\n<p><strong>Date of publication: 01 Janvier 2024<\/strong><\/p>\n<p><strong>Auteurs : : Shaodi Zhu, Shuwen Zeng*, Cyrille V\u00e9zy &amp; Rodolphe Jaffiol, Sik-To Chan\u00a0\u00a0(Light, Nanomaterials &amp; Nanotechnologies (L2n), CNRS-UMR 7076, University of Technology of Troyes, 10000, Troyes, France), Ho-Pui Ho (Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China), \u00a0&amp; Aurelian Crunteanu (XLIM Research Institute, UMR 7252 CNRS\/University of Limoges, 123, Avenue Albert Thomas, Limoges, France),<\/strong><\/p>\n<p><strong>Lien :<a href=\"https:\/\/www.nature.com\/articles\/s41377-023-01345-6\"> https:\/\/www.nature.com\/articles\/s41377-023-01345-6<\/a><\/strong><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rapid plasmonic biosensing offers great potential in the fields of early disease diagnosis and molecular biology research. However, it was still difficult for conventional plasmonic sensors to achieve higher sensitivity without secondary amplification such as plasmonic nanoparticles. To solve this problem, a team of researchers from L2n (CNRS- University of Troyes), the Biomedical Engineering Department [&hellip;]<\/p>\n","protected":false},"author":251,"featured_media":1952,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[],"class_list":["post-1959","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials - Laboratoire d&#039;Excellence \u2211-LIM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials - Laboratoire d&#039;Excellence \u2211-LIM\" \/>\n<meta property=\"og:description\" content=\"Rapid plasmonic biosensing offers great potential in the fields of early disease diagnosis and molecular biology research. However, it was still difficult for conventional plasmonic sensors to achieve higher sensitivity without secondary amplification such as plasmonic nanoparticles. To solve this problem, a team of researchers from L2n (CNRS- University of Troyes), the Biomedical Engineering Department [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en\" \/>\n<meta property=\"og:site_name\" content=\"Laboratoire d&#039;Excellence \u2211-LIM\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-13T15:15:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-05T11:44:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2025\/02\/Image_Highligjt-LABEX.png\" \/>\n\t<meta property=\"og:image:width\" content=\"957\" \/>\n\t<meta property=\"og:image:height\" content=\"610\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"guyotp07@unilim.fr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"guyotp07@unilim.fr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en\",\"url\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en\",\"name\":\"Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials - Laboratoire d&#039;Excellence \u2211-LIM\",\"isPartOf\":{\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2025\/02\/Image_Highligjt-LABEX.png\",\"datePublished\":\"2025-01-13T15:15:21+00:00\",\"dateModified\":\"2025-02-05T11:44:37+00:00\",\"author\":{\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/#\/schema\/person\/90c0ef5253e3a0a24a46b0573d9b5040\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#primaryimage\",\"url\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2025\/02\/Image_Highligjt-LABEX.png\",\"contentUrl\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2025\/02\/Image_Highligjt-LABEX.png\",\"width\":957,\"height\":610},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/#website\",\"url\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/\",\"name\":\"Laboratoire d&#039;Excellence \u2211-LIM\",\"description\":\"Des mat\u00e9riaux et composants c\u00e9ramiques sp\u00e9cifiques aux syst\u00e8mes communicants int\u00e9gr\u00e9s, s\u00e9curis\u00e9s, et intelligents \",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/#\/schema\/person\/90c0ef5253e3a0a24a46b0573d9b5040\",\"name\":\"guyotp07@unilim.fr\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/ac4d3557e3ad9f6b1d4f95763fd7c41147b73f0617f6f266c1dc3c1caca53f4e?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/ac4d3557e3ad9f6b1d4f95763fd7c41147b73f0617f6f266c1dc3c1caca53f4e?s=96&d=mm&r=g\",\"caption\":\"guyotp07@unilim.fr\"},\"url\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/author\/guyotp07unilim-fr\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials - Laboratoire d&#039;Excellence \u2211-LIM","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en","og_locale":"fr_FR","og_type":"article","og_title":"Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials - Laboratoire d&#039;Excellence \u2211-LIM","og_description":"Rapid plasmonic biosensing offers great potential in the fields of early disease diagnosis and molecular biology research. However, it was still difficult for conventional plasmonic sensors to achieve higher sensitivity without secondary amplification such as plasmonic nanoparticles. To solve this problem, a team of researchers from L2n (CNRS- University of Troyes), the Biomedical Engineering Department [&hellip;]","og_url":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en","og_site_name":"Laboratoire d&#039;Excellence \u2211-LIM","article_published_time":"2025-01-13T15:15:21+00:00","article_modified_time":"2025-02-05T11:44:37+00:00","og_image":[{"width":957,"height":610,"url":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2025\/02\/Image_Highligjt-LABEX.png","type":"image\/png"}],"author":"guyotp07@unilim.fr","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"guyotp07@unilim.fr","Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en","url":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en","name":"Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials - Laboratoire d&#039;Excellence \u2211-LIM","isPartOf":{"@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#primaryimage"},"image":{"@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#primaryimage"},"thumbnailUrl":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2025\/02\/Image_Highligjt-LABEX.png","datePublished":"2025-01-13T15:15:21+00:00","dateModified":"2025-02-05T11:44:37+00:00","author":{"@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/#\/schema\/person\/90c0ef5253e3a0a24a46b0573d9b5040"},"breadcrumb":{"@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#primaryimage","url":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2025\/02\/Image_Highligjt-LABEX.png","contentUrl":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2025\/02\/Image_Highligjt-LABEX.png","width":957,"height":610},{"@type":"BreadcrumbList","@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/2025\/01\/13\/label-free-biosensing-with-singular-phase-enhanced-lateral-position-shift-based-on-atomically-thin-plasmonic-nanomaterials\/?lang=en#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.unilim.fr\/labex_sigmalim\/"},{"@type":"ListItem","position":2,"name":"Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials"}]},{"@type":"WebSite","@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/#website","url":"https:\/\/www.unilim.fr\/labex_sigmalim\/","name":"Laboratoire d&#039;Excellence \u2211-LIM","description":"Des mat\u00e9riaux et composants c\u00e9ramiques sp\u00e9cifiques aux syst\u00e8mes communicants int\u00e9gr\u00e9s, s\u00e9curis\u00e9s, et intelligents ","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.unilim.fr\/labex_sigmalim\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/#\/schema\/person\/90c0ef5253e3a0a24a46b0573d9b5040","name":"guyotp07@unilim.fr","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.unilim.fr\/labex_sigmalim\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/ac4d3557e3ad9f6b1d4f95763fd7c41147b73f0617f6f266c1dc3c1caca53f4e?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/ac4d3557e3ad9f6b1d4f95763fd7c41147b73f0617f6f266c1dc3c1caca53f4e?s=96&d=mm&r=g","caption":"guyotp07@unilim.fr"},"url":"https:\/\/www.unilim.fr\/labex_sigmalim\/author\/guyotp07unilim-fr\/"}]}},"_links":{"self":[{"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/posts\/1959","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/users\/251"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/comments?post=1959"}],"version-history":[{"count":2,"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/posts\/1959\/revisions"}],"predecessor-version":[{"id":1962,"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/posts\/1959\/revisions\/1962"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/media\/1952"}],"wp:attachment":[{"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/media?parent=1959"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/categories?post=1959"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-json\/wp\/v2\/tags?post=1959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}