{"id":1863,"date":"2023-08-31T15:58:27","date_gmt":"2023-08-31T15:58:27","guid":{"rendered":"http:\/\/www.unilim.fr\/labex_sigmalim\/?p=1863"},"modified":"2023-09-01T09:58:49","modified_gmt":"2023-09-01T09:58:49","slug":"publication-3d-hydroxyapatite-based-architectures-mimicking-human-trabecular-bone-stereolithographic-development-and-in-vitro-biological-evaluation","status":"publish","type":"post","link":"https:\/\/www.unilim.fr\/labex_sigmalim\/2023\/08\/31\/publication-3d-hydroxyapatite-based-architectures-mimicking-human-trabecular-bone-stereolithographic-development-and-in-vitro-biological-evaluation\/?lang=en","title":{"rendered":"[Publication] 3D hydroxyapatite-based architectures mimicking human trabecular bone: stereolithographic development and in vitro biological evaluation"},"content":{"rendered":"<p>Hydroxyapatite (HA)-based ceramics are widely used as synthetic bone substitutes. However, designing complex three-dimensional ceramic scaffolds remains a major challenge. The aim of this work, carried out as part of the \u00ab\u00a0Bone Mimicking Ceramic Substitutes (MimOsA)\u00a0\u00bb project involving IRCER and the XLIM and PPRIME Institutes, is to develop a porous ceramic scaffold that mimics natural trabecular bone, and to study its biological behavior.<\/p>\n<p>To achieve this, bone samples, taken at the Centre Hospitalier Universitaire de Limoges in accordance with current ethical rules, were scanned using X-ray microtomography to generate a database of 3D models. From this computer-aided design (.STL files), ceramic scaffolds (HA) were shaped layer by layer by additive manufacturing using stereolithography (SLA). This technique enables the direct manufacture of 3D parts with a controlled porous complex architecture (precision in the order of a hundred microns). The parts were then sintered to obtain dense ceramic scaffolds.<\/p>\n<p>The raw and sintered parts thus obtained were compared respectively with the initial .STL files and the human bone model to be reproduced (wall thickness, size and geometry of the pore network) using image analysis. The optimum machine parameters required to produce these mimetic substitutes were then defined.<\/p>\n<p>Human mesenchymal stem cells (hMSC) were cultured to study the biological properties of these structures (attachment and proliferation of hMSC cells). State-of-the-art characterization tools available on the Biscem platform were used to carry out this cellular study. These preliminary biological assessments demonstrate the good biocompatibility and cell adhesion of these substitutes.<\/p>\n<p>Thanks to this initial proof of concept, work is continuing on the \u00ab\u00a0BELENOS\u00a0\u00bb regional project to functionalize these substitutes (integration of antibiotics, etc.).<\/p>\n<h6><a href=\"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2023\/09\/Image-LABEX.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-1865 aligncenter\" src=\"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2023\/09\/Image-LABEX-300x195.png\" alt=\"\" width=\"300\" height=\"195\" srcset=\"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2023\/09\/Image-LABEX-300x195.png 300w, https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2023\/09\/Image-LABEX.png 536w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><em>All stages of the MimOsA project: from the creation of the .STL file (c) from collected human bone (a) scanned by X-ray microtomography (b) to the in vitro study (e) of the resulting sintered ceramic part (d).<\/em><\/h6>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>About the publication<\/strong><\/p>\n<p>Journal: Solid State Phenomena (Volume 339)<br \/>\nPages: 103-108<br \/>\nArticle: Processing by Laser Stereolithography and In Vitro Biological Evaluation of Hydroxyapatite Scaffolds Mimicking Human Trabecular Bone Architecture<\/p>\n<p>Auteurs : by Paul Danty, Amandine Magnaudeix, Emeline Renaudie, Fanny Leborgne, Vincent Pateloup, Valery Valle, Eric Champion*, Patricia Pascuad-Mathieu<br \/>\nLien: <a href=\"https:\/\/doi.org\/10.4028\/p-zn71xt\">https:\/\/doi.org\/10.4028\/p-zn71xt<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hydroxyapatite (HA)-based ceramics are widely used as synthetic bone substitutes. However, designing complex three-dimensional ceramic scaffolds remains a major challenge. The aim of this work, carried out as part of the \u00ab\u00a0Bone Mimicking Ceramic Substitutes (MimOsA)\u00a0\u00bb project involving IRCER and the XLIM and PPRIME Institutes, is to develop a porous ceramic scaffold that mimics natural [&hellip;]<\/p>\n","protected":false},"author":194,"featured_media":1865,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[],"class_list":["post-1863","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>[Publication] 3D hydroxyapatite-based architectures mimicking human trabecular bone: stereolithographic development and in vitro biological evaluation - Laboratoire d&#039;Excellence \u2211-LIM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unilim.fr\/labex_sigmalim\/2023\/08\/31\/publication-3d-hydroxyapatite-based-architectures-mimicking-human-trabecular-bone-stereolithographic-development-and-in-vitro-biological-evaluation\/?lang=en\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[Publication] 3D hydroxyapatite-based architectures mimicking human trabecular bone: stereolithographic development and in vitro biological evaluation - Laboratoire d&#039;Excellence \u2211-LIM\" \/>\n<meta property=\"og:description\" content=\"Hydroxyapatite (HA)-based ceramics are widely used as synthetic bone substitutes. However, designing complex three-dimensional ceramic scaffolds remains a major challenge. The aim of this work, carried out as part of the \u00ab\u00a0Bone Mimicking Ceramic Substitutes (MimOsA)\u00a0\u00bb project involving IRCER and the XLIM and PPRIME Institutes, is to develop a porous ceramic scaffold that mimics natural [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unilim.fr\/labex_sigmalim\/2023\/08\/31\/publication-3d-hydroxyapatite-based-architectures-mimicking-human-trabecular-bone-stereolithographic-development-and-in-vitro-biological-evaluation\/?lang=en\" \/>\n<meta property=\"og:site_name\" content=\"Laboratoire d&#039;Excellence \u2211-LIM\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-31T15:58:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-01T09:58:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unilim.fr\/labex_sigmalim\/wp-content\/uploads\/sites\/8\/2023\/09\/Image-LABEX.png\" \/>\n\t<meta property=\"og:image:width\" content=\"536\" \/>\n\t<meta property=\"og:image:height\" content=\"348\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"guyotp07\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"guyotp07\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/2023\/08\/31\/publication-3d-hydroxyapatite-based-architectures-mimicking-human-trabecular-bone-stereolithographic-development-and-in-vitro-biological-evaluation\/?lang=en\",\"url\":\"https:\/\/www.unilim.fr\/labex_sigmalim\/2023\/08\/31\/publication-3d-hydroxyapatite-based-architectures-mimicking-human-trabecular-bone-stereolithographic-development-and-in-vitro-biological-evaluation\/?lang=en\",\"name\":\"[Publication] 3D hydroxyapatite-based architectures mimicking human trabecular bone: stereolithographic development and in vitro biological evaluation - 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