CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database


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    K599N

    Antiviral assays:

    Antiviral EC50 ratio Phenotype Strain Source Marker Assay Reference
    Ganciclovir 1.10 No resistance Clinical Isolate Recombinant Details Low level drug resistance linked to cytomegalovirus UL97 and UL27 mutations detected in maribavir clinical trials. (Sep 2026)
    Maribavir 1.10 No resistance Clinical Isolate Recombinant Details Low level drug resistance linked to cytomegalovirus UL97 and UL27 mutations detected in maribavir clinical trials. (Sep 2026)

    Mutations at the same locus:

    Mutant Resistances
    599-603del Ganciclovir: High level resistance
    K599E Ganciclovir:
    K599R Ganciclovir: No resistance
    K599T Ganciclovir: High level resistance


    Tilloy et al., 2024
    Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230