CHARMD

Comprehensive Herpesviruses Antiviral drug Resistance Mutation Database

R396S

Virus: Human betaherpesvirus 5
Gene: UL56
Resistance summary:*
- Letermovir: High level resistance

*If there is more than one line per antiviral, please refer to the table below

Antiviral assays:

Antiviral	EC50 ratio	Phenotype	Strain	Source	Marker	Assay	Reference
Letermovir	81.00	High level resistance				Details	Geno- and phenotypic characterization of human cytomegalovirus mutants selected in vitro after letermovir (AIC246) exposure. ( 2014)

Tilloy et al., 2024

Interdeposit Digital Number: IDDN.FR.001.420004.000.S.X.2024.000.31230