CHARMD

TOP

• Mutant: C607Y
• Gene: UL97
• Virus: Human betaherpesvirus 5
• Strain:
• Reference: Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as induction and maintenance therapy for CMV retinitis. (Dec 2001)


• Antiviral: Ganciclovir
• EC50 ratio: 12.50
• Phenotype: High level resistance
• Passage: N/A
• Source: Laboratory strain, Clinical Isolate
• Marker: Recombinant


• Details:
  • PRA, ELISA tests, flow cytometry and DNA-DNA hybridization assays, quantitative real-time PCR, reporter cell lines, polymerase biochemical assays, marker transfer


• Observations:
  • Autre publi ID : 24903568 11807689 12198609 26098499 31940472 Mutation fr?quemment retrouv?e chez les patients re?evant des CS h?matopo?etiques