TOP
First clinical description of letermovir resistance mutation in cytomegalovirus UL51 gene and potential impact on the terminase complex structure.
- Pubmed_id: 35690130
- Journal: Antiviral research
-
Genbank_id: No known Genbank_id
- Date: Aug 2022
- Volume: 204
- Issue: None
- Pages: 105361
-
Author(s):
Muller C,
Tilloy V,
Frobert E,
Feghoul L,
Garrigue I,
Lepiller Q,
Mirand A,
Sidorov E,
Hantz S,
Alain S,
- Abstract: As an isolated mutation in pUL51 in a clinical isolate can lead to LMV resistance, genotyping for resistance should involve sequencing of the pUL51, pUL56 and pUL89 genes. With terminase modelling, we make the hypothesis that LMV could bind to domains were UL56-L257I and UL51-A95V mutations were localized.
