Codex_V5

Putative functional domains of human cytomegalovirus pUL56 involved in dimerization and benzimidazole D-ribonucleoside activity.

Pubmed_id: 18771048
Journal: Antiviral therapy
Genbank_id: No known Genbank_id
Date: 2008
Volume: 13
Issue: 5
Pages: 643-54
Author(s): Champier G, Couvreux A, Hantz S, Rametti A, Mazeron MC, Bouaziz S, Denis F, Alain S,

Abstract: This study provides a basis to investigate the mechanism of concatemeric DNA cleavage and a biochemical basis for DNA packaging inhibition by benzimidazole derivatives.

Mutations:

Mutant	Gene	Virus	EC50 ratio	Phenotype
E2K	UL56	Human betaherpesvirus 5	1.00	No resistance
V12L	UL56	Human betaherpesvirus 5	1.00	No resistance
D242G	UL56	Human betaherpesvirus 5		Natural polymorphism
A327V	UL56	Human betaherpesvirus 5		Natural polymorphism
E393K	UL56	Human betaherpesvirus 5		Natural polymorphism
A425V	UL56	Human betaherpesvirus 5		Natural polymorphism
G436E	UL56	Human betaherpesvirus 5		Natural polymorphism
M442T	UL56	Human betaherpesvirus 5		Natural polymorphism
A444G	UL56	Human betaherpesvirus 5		Natural polymorphism
S445N	UL56	Human betaherpesvirus 5		Natural polymorphism
N446del	UL56	Human betaherpesvirus 5		Natural polymorphism
449-451del	UL56	Human betaherpesvirus 5		Natural polymorphism
T452I	UL56	Human betaherpesvirus 5		Natural polymorphism
S454N	UL56	Human betaherpesvirus 5		Natural polymorphism
G460V	UL56	Human betaherpesvirus 5		Natural polymorphism
A464T	UL56	Human betaherpesvirus 5		Natural polymorphism
V471A	UL56	Human betaherpesvirus 5		Natural polymorphism
V476A	UL56	Human betaherpesvirus 5		Natural polymorphism
E485G	UL56	Human betaherpesvirus 5		Natural polymorphism
R507C	UL56	Human betaherpesvirus 5		Natural polymorphism
Q577R	UL56	Human betaherpesvirus 5		Natural polymorphism
D586N	UL56	Human betaherpesvirus 5		Natural polymorphism
A648R	UL56	Human betaherpesvirus 5		Natural polymorphism
A648S	UL56	Human betaherpesvirus 5		Natural polymorphism
L658F	UL56	Human betaherpesvirus 5		Natural polymorphism
S749N	UL56	Human betaherpesvirus 5		Natural polymorphism
V778A	UL56	Human betaherpesvirus 5		Natural polymorphism
V793A	UL56	Human betaherpesvirus 5		Natural polymorphism
P800L	UL56	Human betaherpesvirus 5		Natural polymorphism
P803A	UL56	Human betaherpesvirus 5		Natural polymorphism
A812E	UL56	Human betaherpesvirus 5		Natural polymorphism
L831M	UL56	Human betaherpesvirus 5		Natural polymorphism
G840A	UL56	Human betaherpesvirus 5		Natural polymorphism
S848N	UL56	Human betaherpesvirus 5		Natural polymorphism