Codex_V5

8-cyclopentyl-1,3-dipropylxanthine

Short name: GCV
Chembl ID: CHEMBL183
SMILES (Simplified Molecular Input Line Entry System): CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3

Mutant	Gene	Type	Virus	EC50 ratio	Phenotype	Assay	Reference
M550I	UL97	SNP	Human betaherpesvirus 5	0.85	No resistance	Details	Characterization of human cytomegalovirus (HCMV) UL97 mutations found in a valganciclovir/oral ganciclovir prophylactic trial by use of a bacterial artificial chromosome containing the HCMV genome. (Sep 2006)
A582V	UL97	SNP	Human betaherpesvirus 5	0.82	No resistance	Details	Characterization of human cytomegalovirus (HCMV) UL97 mutations found in a valganciclovir/oral ganciclovir prophylactic trial by use of a bacterial artificial chromosome containing the HCMV genome. (Sep 2006)
Y617H	UL97	SNP	Human betaherpesvirus 5	0.84	No resistance	Details	Characterization of human cytomegalovirus (HCMV) UL97 mutations found in a valganciclovir/oral ganciclovir prophylactic trial by use of a bacterial artificial chromosome containing the HCMV genome. (Sep 2006)
A674T	UL97	SNP	Human betaherpesvirus 5	0.91	No resistance	Details	Characterization of human cytomegalovirus (HCMV) UL97 mutations found in a valganciclovir/oral ganciclovir prophylactic trial by use of a bacterial artificial chromosome containing the HCMV genome. (Sep 2006)