Florent Di Meo
INSERM Researcher (CRCN) - Computational and Structural Pharmacology
About me...
Three children, Handball player, referee and coach
H-index: 20 (WoK)
ORCID: 0000-0001-6279-1272
ResearcherID: A-1904-2017
RESEARCH ACTIVITIES
Computational and Structural Pharmacology
Multiscale Model for local PK events
Others
Selected Publications
Membrane Transporters
- On the interplay between lipids and asymmetric dynamics of an NBS degenerate ABC transporter, Comm. Biol., 6 (2023), 149
- Computational and structural insights into the pre- and post-hydrolysis states of bovine multidrug resistance-associated protein 1, Basic Clin. Pharmacol. Toxicol., (2023), DOI:10.1111/bcpt.13871
- Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic scale, Biomed. Pharmacother., (2023), 160, 114342
- Insights into the structure and function of the human organic anion transporter 1 in lipid bilayer membranes, Sci. Rep., 2022, 12, 7057
- Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants, Liv. Int., 2021, 41, 1344-1357
- Structural patterns of the human ABCC4/MRP4 exporter in lipid bilayers rationalize clinically observed polymorphisms, Pharmacol. Res., 133, 2018, 318-327
- In Silico Pharmacology: Drug Membrane Partitioning and Crossing, Pharmacol. Res., 111, 2016, 471-486
Others
- Phospholipid-porphyrin conjugates: deciphering the driving forces behind their supramolecular assemblies, Nanoscale, 2022, 14, 7387-7407
- GASP-1 and GASP-2, two closely structural related proteins with a functional duality in anti-trypsin inhibition specificity: a mechanistic point of view, FEBS Journal, 2020, 287, 909-924
- Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging, J. Med. Chem, 2019, 62, 1657-1668.
- Atomistic Picture of Fluorescent Probes with Hydrocarbon Tails in Lipid Bilayer Membranes: An Investigation of Selective Affinities and Fluorescent Anisotropies in Different Environmental Phases, Langmuir, 34, 2018, 9072-9084
- Role of the bridging group in bis-pyridyl ligand: Control of the photo- and electro-luminescent features of (IPr)Cu(I) complexes, Chem. Eur. J., 23, 2017, 16328-16337
- Consequences of conformational flexibility in hydrogen-bond driven self-assembly processes, Chem. Comm., 52, 2016, 10870-10873
- Bottom-up hierarchical self-assembly of chiral porphyrins through coordination and hydrogen bonds, J. Am. Chem. Soc., 137, 2015, 15795–15808
- DNA Electronic Circular Dichroism at the Inter-Base Pair Scale, J. Phys. Chem. Lett., 6, 2015, 355-359
- Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes, Org. Biomol Chem., 13, 2015, 2453-2463
2018-Nowadays
- Modelling membrane crossing of drugs by means of MD simulations: towards in silico pharmacology
- Computational and Structural Pharmacology of membrane transporters
- Deciphering the role of membrane transporters and DME onto local PK events by means of multi-organ-on-chip models
2013-2018:
- Chiral self-assembly: theoretical approach
- Structure-Propertiy Relationship of Copper-carbene complexes: TADF vs Phosphorescence
- Toward the theoretical elucidation of DNA chirality in nucleosomes
- Absorption and emission properties of Copper-carbene complexes
- Chemically induced chirality in Porphyrins
- Chiral self-assemblyBinding mode of porphyrins with DNA G-quadruplexes and chiral properties
- Pigmentation and copigmentation (π-stacking association by DFT-D, charge transfer UV-vis absorption spectra by TD-DFT). Theoretical evaluation of solvent effects: use of explicit or implicit (continuum-based) models
2009-2013
- Molecular and Supramolecular Highlights on Reactivity and Optoelectronics of Natural Polyphenols
- Quantum chemical calculations to rationalize free radical biological events
- Thermodynamics and kinetics of electron transfer and atom transfers of natural antioxidants
- UV/Visible Absorption of natural compounds by means of QM calculations
- 2018-nowadays INSERM researcher (CRCN) at INSERM U1248 IPPRITT
- 2013-2018 Post-Doc at INSERM U850/1248 (Pharmacology of immunosuppressant drugs in transplantation) (University of Limoges – France)
- 2013-2015 Post-Doc in Linköping University, (Theretical Chemistry group – IFM) Linköping (Sweden)
- 2012-2013 Post-Doc in the University of Limoges (Faculty of Sciences) Limoges (France)
- 2009-2012 PhD at the University of Limoges (Faculty of Sciences) Limoges (France)
- 2009 PharmD at the University of Limoges (Faculty of Sciences) Limoges (France)
- 2022 Dalton Division Horizon Prize by Royal Society of Chemistry (RSC)
- “Gaston Berthier” Award by French Theoretical Chemistry Society (Réseau de Chimie Théorique Francophone – RCTF)(2014) of RCPTM (Czech Rep.)
- Invited conferences (3) + several national & international seminars, oral communications
- Reviewer for international journals 1<IF<12
- Collaborative Network
- RCPTM (Olomouc – Czech Rep.)
- LCMN (Mons – Belgium)
- Dpt of Physical Chemistry (Alicante, Spain)
- Faculty of Medecine (Olomouc – Czech Republic)
- Academy of Sciences (Prague – Czech Rep.)
- Univ. Szeged (Szeged, Hungary)
- Division of Theoretical Chemistry and Biology (KTH Stockholm, Sweden)
- CNRS Enzyme and Cell Engineering Laboratory (Compiègne, France)
- CNRS UMR 6507 (Caen, France)
- 2019 Accreditation to supervise research (HDR – French postdoctoral degree)
- 2012 PhD “Molecular and Supramolecular Highlights on Reactivity and Optoelectronics of Natural Polyphenols” – Limoges University
- 2009 Pharmacist – PharmD – Limoges University
- Language
- French: Mother Tongue
- English: daily use + good working knowledge (Medical English Diploma in 2012 – Limoges University)
- Supervision of 3 PhD students
- Co-Supervisor of 2 PhD students
- Several Masters;
- Examination board for few PhDs
- Teaching Experiences (students in Biology & Pharmacy):
- Biophysics,
- Physical Chemistry
- Molecular Modeling and theoretical chemistry
- Structural Biology
- Former member of CoReBioSP – University Hospital Dupuytren Limoges – (Council dedicated to Biomedical Research and Public Heathcare)
- Member of CALI scientific committee (Computational center at Univ. Limoges)
